Clinical application of intervertebral disc repair: development of biological repair

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592193
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Mie University
• Principal Investigator: AKEDA Koji 三重大学, 医学部附属病院, 講師 (20422826)
• Co-Investigator(Kenkyū-buntansha): MIYAMOTO Keiichi 三重大学, 工学(系)研究科(研究院), 准教授 (70252343)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 椎間板変性 / 組織再生 / 多血小板血漿 / 生体材料

Outline of Final Research Achievements

We report the results of a prospective feasibility clinical trial for the use of an intradiscal injection of PRP-releasate in patients with degenerative disc disease (discogenic low back pain). First, no adverse effects were identified following treatment. The intradiscal injection of PRP-releasate has potential to reduce clinical LBP scores in 85% subjects.
The results of this study showed that gellan-sulfate, candidate for disc biomaterial, has potential to affect the matrix metabolism of intervertebral disc cells dependent on the ratio of sulfation. In vivo animal study showed that gellan-sulfate has high tissue compatibility, suggesting the possibility that gellan-sulfate would be effective biomaterial for intervertebral disc degeneration.

Free Research Field

椎間板再生