The pathomechanism of nociceptive pain and neuropathic pain in herniated disc disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592195
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kobe University
• Principal Investigator: TAKADA Toru 神戸大学, 医学(系)研究科(研究院), 医学研究員 (00598526)
• Co-Investigator(Kenkyū-buntansha): NISHIDA Kotaro 神戸大学, 医学研究科, 講師 (00379372) ; KAKUTANI Kenichiro 神戸大学, 医学部附属病院, 助教 (10533739) ; MAENO Koichiro 神戸大学, 医学研究科, 助教 (70403269)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 椎間板変性 / 侵害受容性疼痛 / 神経障害性疼痛

Outline of Final Research Achievements

We have previously shown that intervertebral disc and macrophages interaction induces pro-inflammatory reaction and pain related behavior. We clarified macrophages existence in degenerative disc not only in herniated disc disease but also lumbar canal stenosis. M1 macrophage, which plays inflammatory and tumoricidal activity, is exists in 95.5% of herniated disc disease and 95.6% of lumbar canal stenosis.

Free Research Field

医歯薬学