To elucidate the mechanism of tranilast treatment on extra-abdominal desmoid tumor

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592223
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: SHINODA Yusuke 東京大学, 医学部附属病院, 講師 (80456110)
• Co-Investigator(Kenkyū-buntansha): 河野 博隆 東京大学, 医学部附属病院整形外科 (20345218)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 骨・軟部腫瘍学

Outline of Final Research Achievements

We performed a probabilistic analysis of the clinical effect of tranilast treatment on desmoid tumor. There is not an apparent tendency of the effect of tranilast to the tumor, but no side effect was observed. To analyze the mechanism of tranilast, we used the β-catenin over-expressed mouse embryonal fibroblast and tumor cell derived from desmoid tumor. These experiments revealed that tranilast had an effect on not canonical pathway of Wnt/β-catenin signal but non-canonical pathway. We are now going on to analyze the correlation of the clinical effect of tranilast with this Wnt/β-catenin non-canonical pathway.

Free Research Field

骨・軟部腫瘍学