2014 Fiscal Year Final Research Report
Analyses of IKK signaling pathway in locomotive diseases
| Project/Area Number |
24592253
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Hiroshi 東京大学, 医学部附属病院, 届出診療医 (40282660)
CHIKUDA Hirotaka 東京大学, 医学部附属病院, 准教授 (30345219)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 整形外科学 / 変形性関節症 |
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| Outline of Final Research Achievements |
IKK family members were highly expressed in the mouse embryonic cartilage and articular cartilage of knee joints of osteoarthritis model mice. Rela, a transcription factor of NF-kB signaling pathway, was translocated from cytoplasm into nuculeus in accordance with cartilage degradation. For in vivo analyses, we generated tamoxifen-inducible conditional knockout mice. Notably, osteoarthritis development was enhanced in homo knockout mice, while it was suppressed in hetero knockout mice.
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| Free Research Field |
整形外科学
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