Research on the prevention of osteonecrosis of the femoral head by analyzing genetic polymorphism

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592274
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: INOUE Shigehiro 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (10184748)
• Research Collaborator: HAYASHI Shigeki 京都府立医科大学, 医学研究科
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 特発性大腿骨頭壊死症 / 遺伝子多型 / SNPs

Outline of Final Research Achievements

The purpose of this study is to prevent steroid-induced osteonecrosis of the femoral head (ONFH) by analyzing genetic polymorphism. First, we made a short list of candidate gene by primary screening with microarray. Then, we tried to detect the gene related with the steroid-induced ONFH by analyzing the base sequence of the candidate gene and analyze the single nucleotide polymorphism (SNPs) of the candidate gene. We detected the SNPs related with steroid-induced ONFH, and analyzed the association with each SNPs. However, we cannot detect the new SNPs related with steroid-induced ONFH.

Free Research Field

医歯薬学