The expression of nerve elements and the effect of hyaluronic acid for the injury of the enthesis

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592276
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Nara Medical University
• Principal Investigator: Kumai Tsukasa 奈良県立医科大学, 医学部, 教授 (40382288)
• Co-Investigator(Kenkyū-buntansha): TANAKA Yasuhito 奈良県立医科大学, 医学部, 教授 (30316070)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: enthesis / neural element / enthesis organ / neuropeptide / hyaluronic acid

Outline of Final Research Achievements

To clarify the pathogenesis of the injury of the attachment of the tendon/ligament (i.e. enthesis), we investigated the nerve elements and angiogenesis, which might cause some symptoms, such as pain, and the repair reaction. We demonstrated that they were present at synovial adipose tissue around the enthesis (i.e. enthesis organ). In this study, Although the blood vessels increase strongly after the injury of the enthesis, it was unable to clear whether nerve elements react strongly. The administration of hyaluronic acid to the injury site of the enthesis, compared to the non-administration group, it was found that the repair response to injury occurs more rapidly (promoting action).

Free Research Field

整形外科、スポーツ医学