Analysis of the mechanism for joint destruction via SDF-1 in rheumatoid arthritis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592284
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: KANBE Katsuaki 東京女子医科大学, 医学部, 准教授 (70366326)
• Co-Investigator(Renkei-kenkyūsha): INOUE Yasuo 東京女子医科大学, 医学部, 助教 (00408519)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 関節リウマチ / 滑膜 / 組織 / 免疫染色 / SDF-1 / CXCR4 / 関節破壊

Outline of Final Research Achievements

Using an immunohistological analysis of synovium from rheumatoid arthritis (RA), we determined whether disease activity and joint destruction were correlated with the levels of SDF-1 and CXCR4 by IH scores [1]. SDF-1 was strongly correlated with the DAS28 CRP and serum IL-6. CXCR4 was correlated with synovial CD4 and the Assessment of RA by Scoring of Large-Joint Destruction and Healing in Radiographic Imaging (ARASHI) score. CD4 was correlated with the van der Heijde-modified Sharp (vdH-S) score. Therefore synovial SDF-1 was correlated with disease activity, and its receptor CXCR4 was related to large joint destruction in RA. In this study, T lymphocyte expressed CD4 via SDF-1/ CXCR4 axis is possible to be important for the mechanism of joint destruction in RA.
1.Kanbe K, et al. Modern Rheumatology 24:910-914,2014.

Free Research Field

整形外科