The prevention of steoid-induced osteonecrosis by intravenous administration of BM-MSC

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592287
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kanazawa Medical University
• Principal Investigator: ICHISEKI Toru 金沢医科大学, 医学部, 准教授 (30307631)
• Co-Investigator(Kenkyū-buntansha): UEDA Yoshimichi 金沢医科大学, 医学部, 教授 (50271375) ; MATSUMOTO Tadami 金沢医科大学, 医学部, 教授 (90173905) ; KANEUJI Ayumi 金沢医科大学, 医学部, 教授 (00303305)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 大腿骨頭壊死 / angiogenesis / 骨髄由来間葉系組織幹細胞 / aquaporin 1 / osteogenesis

Outline of Final Research Achievements

It was considered that formation of Angiogenesis-Osteogenesis coupling disturbance was necessary for occurrence of bone cell necrosis.
It was clear that prevention effect using BM-MSC was very high within 1 day after steroid administration.The effect of prevention in steroid-induced osteonecrosis rabbit models using Ex vivo extended BM-EPC was similar, and that an intravenous administration gives us the high osteonecrosis preventive effect indicated 1 day after steroid administration.And the prevention effects of steroid-induced osteonecrosis by using ex vivo extended BM-MSC and/or BM - EPC were higher than using BM-MNC .The formation of AOC disturbance plays the important role in the development of osteonecrosis, and we consider that this knowledge will be useful for future's study.Since it was clear that the problem in the prevention of osteonecrosis, however, we will continue this study.

Free Research Field

医歯薬学