Novel monitoring systems for consciousness and memory during anesthesia

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592293
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kanazawa University
• Principal Investigator: YAMAMOTO Ken 金沢大学, その他部局等, 名誉教授 (90019638)
• Co-Investigator(Kenkyū-buntansha): TSUBOKAWA Tsunehisa 東京慈恵会医科大学, 医学部, 教授 (80283109)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳磁図 / 脳波 / 意識 / 記憶 / 痛み

Outline of Final Research Achievements

To establish novel bedside monitoring methods for consciousness, memory and pain during anesthesia, we observed brain activities(BA) by magnetoencephalography (MEG), because MEG results are easily applied to electroencephalography (EEG). First, we observed BA during spontaneous sleeping, and found the foci of spindle, theta and delta waves. These data are available to develop the new EEG monitoring methods for consciousness in the future, but we could not observe BA under general anesthesia, because the ethics committee did not allow the experiment. Second, we tried to find the specific changes of BA by memory formation or recollection. We found some changes related to memory, while these changes were not specific,. Third, we observed the changes caused by pain. We used harmless ice pack as pain stimulator and found pain-specific changes in the amygdala, hypocampus, insula and anterior cingulate gyrus. Some of these BA would contribute to establishment of pain monitoring system.

Free Research Field

麻酔・蘇生学