The establishment of strategy for perioperative central nerve protection by NO inhalation therapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592294
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Gifu University
• Principal Investigator: IIDA HIROKI 岐阜大学, 医学(系)研究科(研究院), 教授 (30159561)
• Co-Investigator(Kenkyū-buntansha): TAKENAKA Motoyasu 岐阜大学, 大学院医学系研究科, 准教授 (40227046) ; IIDA Mami 岐阜大学, 大学院医学系研究科, 非常勤講師 (80350859)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: NO吸入 / 脊髄虚血 / 脳虚血 / 脳・脊髄血流 / 中枢神経保護 / 血管内皮保護 / 再灌流障害

Outline of Final Research Achievements

NO inhalation is now known to have protective effect even in distant organs. The purpose of the present study is to prove the usefulness of perioperative NO inhalation therapy for the central nervous protection. Thus, using the spinal cord ischemia animal model, the effect of NO inhalation (80ppm) on spinal cord tissue oxygen partial pressure (PspO2) and spinal cord blood flow (r-SCBF) was examined. As a result, PspO2 in NO inhalation group was significantly improved compared than that in control group (non-NO inhalation) at ischemic period (after aortic clamping to aortic de-clamping). However, in reperfusion period such differences were not found. r-SCBF also showed the similar change with PspO2 that maintained significantly by NO inhalation during spinal cord ischemia. After reperfusion, the effect of NO inhalation was attenuated because of aerobic environment.
Therefore, NO inhalation therapy could be suggested to contribute on the protection of central nervous system.

Free Research Field

医歯薬学