Anesthetic effect on dynamics of membrane microdomains in living cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592301
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kagawa University
• Principal Investigator: ONO Junichiro 香川大学, 医学部附属病院, その他 (90363217)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Shingo 香川大学, 医学部・神経機能形態学, 助教 (50451430)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: マイクロドメイン / 揮発性麻酔薬 / 麻酔メカニズム / FRAP解析 / TIRFM解析

Outline of Final Research Achievements

Lipid rafts are membrane microdomains which abundantly contain sphingolipids, sterols, and receptor proteins. Lipid rafts has crucial role in the signal transduction. Volatile anesthetics with high affinity to lipid distribute in the lipid bilayer. Therefore, it is likely that lipid rafts is target of volatile anesthetic action. The objective of this study is to determine whether the dynamics of lipid raft is affected by volatile anesthetics.

Free Research Field

麻酔科学