Usege of lentiviral vector for treatment of pulmonary hypertension

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592309
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Yokohama City University
• Principal Investigator: WATANABE Itaru 横浜市立大学, 医学(系)研究科(研究院), 客員教授 (20534142)
• Co-Investigator(Kenkyū-buntansha): MIZUNO Yusuke 横浜市立大学, 附属病院, 准教授 (80433192) ; KAWAKAMI Hiromasa 横浜市立大学, 市民総合医療センター, 助教 (90407958) ; BABA Yasuko 横浜市立大学, 市民総合医療センター, 講師 (80453041)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 右室肥大 / PAC1 / PACAP / 心臓神経

Outline of Final Research Achievements

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multifunctional neuropeptide. Although the heart has VIP and PACAP signaling systems including the ligand and receptors, however, involvement of PACAP in cardiac hypertrophy and subsequent heart failure are still unknown. Recently,VIP and PACAP have been reported to have cardioprotective effect and be associated with heart failure.
In this study, elevated PACAP signaling was associated in hypertrophic right ventricles and heart failure induced with monocrotaline in rats. In addition, intravenous administration of PACAP but not VIP improved cardiac output. Therefore,PACAP may play an important roles in right cardiac hypertrophy. However, further study will be necessary to clarify the role in detail and the mechanism.

Free Research Field

麻酔学