Safety anesthesia management for Alzheimer's disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592311
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nagoya City University
• Principal Investigator: SOBUE Kazuya 名古屋市立大学, 医学(系)研究科(研究院), 教授 (90264738)
• Co-Investigator(Kenkyū-buntansha): SUGIURA Takeshi 名古屋市立大学, 大学院医学研究科, 講師 (20295611) ; ASAI Kiyofumi 名古屋市立大学, 大学院医学研究科, 教授 (70212462)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 認知症 / アルツハイマー / 麻酔薬

Outline of Final Research Achievements

The use of anesthetics for the Alzheimer's type dementia (AD) patients, there is a possibility that exacerbate the pathology. The purpose of this study was to clarify the effects of anesthetic drugs on the pathology of AD, it is to establish a secure anesthesia methods. As the pathogenesis of AD, it has been found that GM1 ganglioside is to promote the polymerization of amyloid β (Aβ). Propofol, thiopental, midazolam will become apparent to suppress the expression of GM1, it is likely to be used safely. Ketamine reduces the activity of neprilysin are enzymes that degrade Aβ, may promote Aβ accumulation. As a result of the above it is useful in the establishment of safe anesthesia for AD patients.

Free Research Field

麻酔科学