The impact of neuromuscular blocking agents on central nervous system

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592317
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Jikei University School of Medicine
• Principal Investigator: UEZONO SHOICHI 東京慈恵会医科大学, 医学部, 教授 (10291676)
• Co-Investigator(Kenkyū-buntansha): HOBO Shotaro 東京慈恵会医科大学, 麻酔科学講座, 助教 (60385359) ; SUNAGA Hiroshi 東京慈恵会医科大学, 麻酔科学講座, 講師 (80317966)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 筋弛緩薬 / パンクロニウム / 吸入麻酔薬 / 中枢神経 / 脳室内投与 / 麻酔深度 / ラット

Outline of Final Research Achievements

We examined the effect of neuromuscular blocking agent injected into the lateral ventricle on depth of anesthesia with volatile anesthetic in rats. The tail clamps were applied after the microinjection of pancuronium under isoflurane anesthesia, and their responses (movement or immobilization) were determined.
Pancuronium given into the lateral ventricle significantly increased the rate of occurrence of immobilization even at the dose of 5% of intravenous ED95 for neuromuscular blockade. It shows that pancuronium in the cerebrospinal fluid enhances the depth of anesthesia with isoflurane. This finding suggests that neuromuscular blocking agents even with intravenous injection might affect the depth of anesthesia with volatile anesthetics in clinical settings, and their effects might contribute delayed emergence from anesthesia or postoperative complications.

Free Research Field

医歯薬学