Mechanism elucidation of the general anesthesia from a view point of the changes in the internal gene expression

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592318
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nippon Medical School
• Principal Investigator: SAKAMOTO Atsuhiro 日本医科大学, 医学(系)研究科(研究院), 教授 (30196084)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 全身麻酔 / 遺伝子発現 / microRNA / TLDA / 吸入麻酔薬 / 静脈麻酔薬

Outline of Final Research Achievements

The effects of general anesthetics on the changes of internal gene expression, especially microRNA (miRNA) expression were evaluated mainly by TaqMan Low-density Array (TLDA) analysis. The main results are as follows. (1) The general anesthetics affect miRNA expression in the vital organs (lung, liver, blood, brain and supine). (2) The different anesthetics show the different influence on miRNA expression. (3) The pathologic changes of the central nervous system influence the expression of some miRNAs. These results provide the basic data of miRNA expression for the mechanism elucidation of the general anesthesia.

Free Research Field

麻酔科学