2014 Fiscal Year Final Research Report
The role of glycine receptor alpha3 subunit as a candidate of novel treating target for chronic pain
| Project/Area Number |
24592326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 慢性疼痛 |
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| Outline of Final Research Achievements |
In this study, I have demonstrated the role of glycine receptors in the spinal cord that is involved in a pain sensation pathway. To inhibit the expression of glycine receptor α3 subunits in the rat spinal cord, siRNA was injected to the subarachnoid space. However, the responses to heat stimulus was not changed even after the injection of siRNA. This result suggested that glycine receptor α3 subunits did not have an essential role for the transmission of pain sensation under normal condition. I expect that this result would facilitate the study to uncover the role of glycine receptor α3 subunits in inflammatory pain.
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| Free Research Field |
麻酔科学
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