Non-genomic antinociceptive effects of glucocorticoids on rat spinal cord

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592330
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Niigata University
• Principal Investigator: IKOMA miho 新潟大学, 医歯(薬)学総合研究科, 特任准教授 (30432082)
• Co-Investigator(Kenkyū-buntansha): KOHNO Tatsuro 新潟大学, 医歯学系, 准教授 (00313536)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ステロイド / 脊髄 / 疼痛 / パッチクランプ

Outline of Final Research Achievements

Glucocorticoids play a significant role in the anti-inflammatory effects, however the mechanisms that systemic or epidural administrations of glucocorticoid reduce pain have not been clearly understood. Recent evidence shows that glucocorticoid might cause rapid effect through pathways other than the genomic pathway, which appears in seconds or a few minutes. Although these non-genomic effects have reported in many organs, there are few reports about the effect on sensory-related neuron until now. Glucocorticoid receptors have also been located in spinal cord dorsal horn neuron. To gain an understanding of the mechanisms, we investigated the rapid non-genomic effects of gluticorticoid, dexamethasone and hydrocortisone on excitatory synaptic transmission in the substantia gelatinosa (SG) neurons of the adult rat spinal cord. We found that dexamethasone and hydrocortisone did not alter presynaptic glutamate release.

Free Research Field

疼痛