Effects of volatile anesthetics on cardiac protection via transient receptor potential canonical(TRPC) channels

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592335
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Shiga University of Medical Science
• Principal Investigator: HIROTOSHI Kitagawa 滋賀医科大学, 医学部, 教授 (50252391)
• Co-Investigator(Kenkyū-buntansha): YAMAZAKI Toji 滋賀医科大学, 医学部, 非常勤講師 (20116122)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 吸入麻酔薬 / TRPCチャネル / 心筋保護 / 虚血再灌流傷害 / マイクロダイアリシス

Outline of Final Research Achievements

We examined the effects of volatile anesthetics on ischemic myocardial injury via transient receptor potential canonical (TRPC) channels. The cardiac microdialysis technique was applied to the rat transverse aortic constriction (TAC) model, which is an experimental model for pressure overload-induced cardiac hypertrophy with TRPC channels activation. Using these rat model, ischemia/reperfusion induced cardiac marker levels were elevated. These were suppressed by the pretreatment of 2-APB, SKF96365 (TRPC channel blocker) and sevoflurane. These results suggest that sevoflurane might exert an in vivo myocardial protective effect during ischemia/reperfusion through　TRPC channels.

Free Research Field

周術期管理学