Early prediction of acute kidney injury biomarkers after endovascular stent graft repair of aortic aneurysm

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592337
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Osaka University
• Principal Investigator: UETA kazuyoshi 大阪大学, 医学(系)研究科(研究院), 助教 (90432533)
• Co-Investigator(Kenkyū-buntansha): IGUCHI Naoya 大阪大学, 大学院医学系研究科, 助教 (00372623)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 急性腎障害 / NGAL / バイオマーカー / 大動脈ステント手術

Outline of Final Research Achievements

Acute kidney injury (AKI) is a common and serious condition usually detected some time after onset by changes in serum creatinine (sCr). Although stent grafting to repair aortic aneurysms is associated with AKI caused by surgical procedures or the use of contrast agents, early biomarkers for AKI have not been examined in stent graft recipients. We studied early biomarkers for AKI in patients who had received stent graft repairs of aortic aneurysms.
6 (14%) of 42 retained patients developed AKI. NGAL corrected with urine Cr (NGAL/Cr) values demonstrated the best predictive value for AKI (97% specificity, 83% sensitivity at a 65.1microg/gCr cutoff). Although NGAL/Cr, L-FABP/Cr, L-FABP, NAG, Alb/Cr all reached peak values before AKI detection by sCr in AKI patients, all biomarkers reached cut off value before AKI detection after adaption of cut off value. After stent graft repair of aortic aneurysm, NGAL/Cr is a potentially useful early biomarker for AKI.

Free Research Field

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