The therapeutic effect of inhalation of hydrogen sulfide against sepsis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592348
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: University of the Ryukyus
• Principal Investigator: TERUYA KOUJI 琉球大学, 医学(系)研究科(研究院), 助教 (50437985)
• Co-Investigator(Kenkyū-buntansha): OSHIRO Masakatsu 琉球大学, 医学部附属病院, 助教 (00315483) ; FUCHIGAMI Tatsuya 琉球大学, 医学部附属病院, 講師 (10381211) ; KAMIZATO Kota 琉球大学, 医学部附属病院, 助教 (10554454) ; KAKINOHANA Manabu 琉球大学, 大学院医学研究科, 教授 (20274897)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 敗血症 / 硫化水素 / 炎症性サイトカイン / HMGB1

Outline of Final Research Achievements

We investigated whether inhalation of hydrogen sulfide could prevent septic condition after LPS administration in mice. Our results showed that inhalation of hydrogen sulfide could improve survival rate and completely suppress expression of inflammatory cytokine after LPS administration in mice. And inhalation of hydrogen sulfide was able to inhibit transition of HMGB1 from nuclei into cytoplasm. Our results suggested that inhalation of hydrogen sulfide might potentially improve survival rate via inhibition of cytokine expression during sepsis.

Free Research Field

集中治療医学