2014 Fiscal Year Final Research Report
Study on the relationship between metallothionein-deficiency and pain in CRPS
| Project/Area Number |
24592351
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 複合性局所疼痛症候群 / CRPS / メタロチオネイン |
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| Outline of Final Research Achievements |
Metallothioneins (MT) are low molecular weight (6-7 kDa) metal binding proteins. We previously reported that MT-I/II defected in the injured peripheral nerve from the patients with complex regional pain syndrome (CRPS)-2 and painful neuroma using a proteomics approach. CRPS is a chronic pain disorder displayed a characteristics of neuropathic pain, which is caused by nerve injury or diseases, such as cancer or diabetes. Here, we revealed that MTs were decreased in the injured nerve of neuropathic pain model rats generated by partial ligation of sciatic nerve and that administration of the recombinant human MT-IIA to the periphery of ligation site of model rats improved painful behavior. These results suggest that MT in injured peripheral nerve contributes to neuropathic pain.
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| Free Research Field |
生化学
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