Clarification of mechanism of lumbar discogenic pain

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592354
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: IBUKI Takae 京都府立医科大学, 医学(系)研究科(研究院), 講師 (90232587)
• Co-Investigator(Kenkyū-buntansha): MATSUMURA Kiyoshi 大阪工業大学, 工学部, 教授 (10157349)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 腰痛 / プロスタグランジン / 炎症 / 椎間板性腰痛

Outline of Final Research Achievements

Lifetime susceptibility of lumbar pain among Japanese people is approximately 85% and prompt measures need to be taken. In this study, we tried to elucidate mechanism of lumbar discogenic pain focusing on prostaglandin (PG) synthesis and inflammatory cytokines. COX-1 was strongly expressed in the lumbar discs and neighboring tissues and its expression did not change following disc puncture. COX-2 was not expressed in normal animals, but strong expression was observed in punctured disc and surrounding tissues 24 hours following disc puncture. Using peripheral inflammatory pain model, we found that PG synthesis is dependent on COX-2 and mPGES-1 expression and iPLA2 is involved in the expression of COX-2. Further, behavioral hyperalgesia was correlated with expression of PG synthesis in peripheral inflammatory pain model. Involvement of PG synthesis in lumbar discogenic pain would be elucidated.

Free Research Field

麻酔学