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2014 Fiscal Year Final Research Report

Molecular mechanism of chronic pain via histone-dependent peripheral sensitization

Research Project

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Project/Area Number 24592356
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionWakayama Medical University

Principal Investigator

KIGUCHI Norikazu  和歌山県立医科大学, 医学部, 講師 (90433341)

Co-Investigator(Kenkyū-buntansha) KISHIOKA Shiroh  和歌山県立医科大学, 医学部, 教授 (60137255)
KOBAYASHI Yuka  和歌山県立医科大学, 医学部, 助教 (20511562)
FUKAZAWA Yohji  関西医療大学, 保健医療学部, 准教授 (70336882)
Research Collaborator SAKAGUCHI Haruka  
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords慢性疼痛 / 神経障害性疼痛 / ヒストン / マクロファージ / ケモカイン / エピジェネティクス / 炎症 / サイトカイン
Outline of Final Research Achievements

We focused on the roles of histone, a nuclear protein, in molecular mechanisms of chronic pain. Immune cells including macrophages were accumulated in the injured nerves, and they produced pain-facilitating molecules such as chemokines. We found that these expressions were mediated by modification (acetylation and methylation) of histones. Moreover, macrophages were polarized into pain-facilitating phenotype by histone modification. We demonstrated that inhibition of these types of macrophages by pharmacological treatment was able to improve chronic pain. Taken together, histone modification in macrophages might be key machinery of chronic pain, and it will be candidate of novel therapeutic target.

Free Research Field

薬理学、神経科学

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Published: 2016-06-03  

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