Preventing effect of hydroxyethyl starch solution on endothelial glycocalyx under injury

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592365
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Hyogo Medical University
• Principal Investigator: TATARA Tsuneo 兵庫医科大学, 医学部, 教授 (30207039)
• Co-Investigator(Renkei-kenkyūsha): UEKI Ryusuke 兵庫医科大学, 医学部, 講師 (10340986)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 代用血漿製剤 / グリコカリックス

Outline of Final Research Achievements

Hydroxyethyl starch (HES) solution is a most widely used plasma substitute to treat hypovolemia during perioperative period. This study investigated the effects of HES on the endothelial glycocalyx structure using polyacrylamide gel. We also analyzed these effects and plasma volume expanding effects of HES during surgery. It was found that HES decreased permeability of polyacrylamide gel. On the other hand, plasma volume expanding effects of HES during surgery were inconsistent. These findings suggest that HES modulates permeability of endothelial glycocalyx by changing structure of endothelial glycocalyx.

Free Research Field

麻酔科学