2014 Fiscal Year Final Research Report
Transeesophageal spinal echography and platelet activity
| Project/Area Number |
24592368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MISHIMA Yasunori 久留米大学, 医学部麻酔学講座, 准教授 (30258476)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 血小板機能 / 経食道エコー / 脊髄解剖 |
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| Outline of Final Research Achievements |
The detail of spinal structure can be seen through the spinal disk with the transesophageal echography.However, the range of view was limitted below the 1st lumbar windows through spinal disk. Augmentation of area supplied by the spinal artery was not seen with the contrast echography. Transesophageal spinal echography was useful for the diagnosis of the spinal ischemia.
The patients discontinued with antiplatelet therapy may be exposed to a risk of thrombotic events wich coukd cause the delayed spinal ischemia. The aim of this study is to evaluate the antiplatelet effect of flurbiprofen in patients who underwent surgery. Our preliminary data demonstrated that flurbiprofen inhibited platelet aggregation induced by collagen. Nonsteroidal anti-inflammatory drugs may include the possibility of temporary replacement of aspirin. Our findings showed that the administration of flurbiprofen can inhibit platelet aggregation and maybe useful to avoid the delayed spinal ischemia.
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| Free Research Field |
麻酔学
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