2014 Fiscal Year Final Research Report
Diet-induced macrophage inhibitory cytokine 1 and prostate cancer progression.
| Project/Area Number |
24592374
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Akita University |
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Principal Investigator |
HUANG Mingguo 秋田大学, 医学(系)研究科(研究院), 助教 (60448503)
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| Co-Investigator(Kenkyū-buntansha) |
NARITA Shintaro 秋田大学, 大学院医学系研究科, 講師 (40396552)
TSUCHIYA Norihiko 秋田大学, 大学院医学系研究科, 准教授 (70282176)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | prostate cancer / high-fat diet / palmitic acid / MIC-1 |
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| Outline of Final Research Achievements |
In the present study, high-fat diet (HFD) containing Palmitic acid (PA) promoted growth and invasiveness of prostate cancer (PCa) cells through the upregulation of MIC1 expression. In addition, HFD modulates fatty acid synthase (FASN) expression, which may be an important mechanism in HFD-associated PCa progression.
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| Free Research Field |
泌尿器系癌
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