Risk group stratification to predict prognosis in Japanese patients with urothelial carcinoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592393
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Yamaguchi University
• Principal Investigator: SAKANO Shigeru 山口大学, 医学部, 特別医学研究員 (60363107)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 尿路上皮癌

Outline of Final Research Achievements

Combined ERCC1 and XRCC1 expression may serve as an independent prognostic marker for survival in bladder cancer patients receiving combined trimodality therapy. Prospective studies with a larger sample size are required to confirm these results.
Risk group stratification based on preoperative clinical T stage, voided urine cytology, and WBC counts may be useful for selection of UUT-UC patients for neoadjuvant chemotherapy. Prospective studies with larger numbers of patients and a longer follow-up period are needed to confirm our results.
UTUC with variant histology might be a phenotype of high-grade, locally aggressive advanced tumors rather than of systemic disease. Variant histology may be useful for selection of patients with pT3 and more invasive UTUC for adjuvant therapy. Prospective studies in a larger number of patients with a centralized pathological review are needed to confirm our results.

Free Research Field

泌尿器腫瘍学