Development of a new therapy for prostate cancer by the fusion of the thermotherapy mediated by magnetic field and the immunotherapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592403
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: KAWAI Noriyasu 名古屋市立大学, 医学(系)研究科(研究院), 講師 (20254279)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Takeshi 中部大学, 生物機能開発研究所, 教授 (10043324) ; KOHRI Kenjiro 名古屋市立大学, その他の部局, 学長 (30122047) ; TOZAWA Keiichi 名古屋市立大学, 大学院医学研究科, 准教授 (40264733) ; SASAKI Shoichi 名古屋市立大学, 大学院医学研究科, 准教授 (50225869) ; NAIKI Taku 名古屋市立大学, 大学院医学研究科, 研究員 (50551272)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 温熱治療 / 温熱免疫 / 前立腺癌 / ナノテクノロジー / 磁場

Outline of Final Research Achievements

We developed several years ago new cancer thermotherapy “MCL Heat Therapy”, which is based on the particular character of the magnetite (Fe3O4). The character is generating heat by irradiation of alternative magnetic field. We performed basic research for the purpose of developing new therapy to treat both primary and metastatic lesion by which MCL Heat Therapy and cancer immunotherapy are fused. In vitro, we could not find the enhancement of tumor antigen from prostate cancer cell by heat therapy. However, in vitro, helper T cell and cytotoxic T cell were appeared in tumor tissue by MCL Heat Therapy.
Under the acceptance of Institutional Review Bore of our university, new Heat Therapy with inductive heating machine RF-8 and local injection of MCL was performed for three patients. There were no adverse events.

Free Research Field

泌尿器系腫瘍学