2014 Fiscal Year Final Research Report
Resistance to mTOR inhibitor in metastatic dialysis-related renal cell carcinoma
| Project/Area Number |
24592410
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OYA Mototsugu 慶應義塾大学, 医学部, 教授 (00213885)
ASANUMA Hiroshi 慶應義塾大学, 医学部, 講師 (70245570)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 透析腎癌 |
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| Outline of Final Research Achievements |
In dialysis-related renal cell carcinoma, mTOR was more strongly activated compared with conventional renal cell carcinoma. In addition, constitutive activation was also found in renal tubular cell in dialysis kidney, which would affect dialysis-related cancer initiation. Tyrosine kinase inhibitors accelerated mTOR activation in dialysis-related renal cell carcinoma.
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| Free Research Field |
泌尿器癌全般
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