The evaluation of the function with Manserin in prostate cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592419
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: SOGA NORIHITO 愛知県がんセンター(研究所), 腫瘍医化学部, 研究員 (60332714)
• Co-Investigator(Kenkyū-buntansha): NARITA Masaaki 三重大学, 医学系研究科, 教授 (80302404) ; SUGIMURA Yoshiki 三重大学, 医学系研究科, 教授 (90179151) ; ISHII Kenichiro 三重大学, 医学系研究科, 助教 (90397513)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 前立腺癌 / 神経内分泌分化 / マンセリン / 細胞増殖 / 血管新生

Outline of Final Research Achievements

The expression levels of manserin were quite different in LNCaP cells and sublines, high level in LNCaP and relative low level in F10. Additionally, manserin may induce NE differentiation in LNCaP cells associated with increased expression of vascular endothelial growth factor, but stimulated proliferation in F10 cells. Therefore, our data supported that manserin contributed to cancer progression via multiple functions, including stimulation of angiogenesis and proliferation.

Free Research Field

泌尿器科学