2014 Fiscal Year Final Research Report
A novel genetically-engineered HSV-1 for treatment of chronic pain
| Project/Area Number |
24592421
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITOU Nobuko 東京大学, 医学部附属病院, 講師 (80332609)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 遺伝子治療 / 疼痛 / ヘルペスウイルス / 間質性膀胱炎 |
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| Outline of Final Research Achievements |
Chronic pain is a serious medical condition. We constructed a novel genetically-engineered Herpes Simplex virus-1 (HSV-1) for treatment of chronic pain. The new virus, T3-X, expresses the morphine-like molecule even at latency. We tested the efficacy of T3-X in a mouse model of chronic neuropathic pain. Gene transfer and expression by HSV-1 may be suitable for developing treatments for chronic pain.
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| Free Research Field |
医歯薬学
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