Creation of chronic cystitis animal model which mimics interstitial cystitis and evaluation of intravesical instillation of adipose derived stem cell to IC model bladder

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592422
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: The University of Tokyo
• Principal Investigator: NIIMI Aya 東京大学, 医学部附属病院, 助教 (00376451)
• Co-Investigator(Kenkyū-buntansha): NOMIYA Akira 東京大学, 医学部泌尿器外科学, 助教 (30372379) ; NISHIMATUS Hiroaki 東京大学, 医学部泌尿器外科学, 准教授 (60251295) ; IGAWA Yasuhiko 東京大学, 医学部コンチネンス医学講座, 特任教授 (40159588) ; HOMMA Yukio 東京大学, 医学部泌尿器外科学, 教授 (40165626)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Etsu 聖マリアンナ医科大学, 難病治療研究センター, 講師 (40313134)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 泌尿器科学 / 排尿機能学 / 間質性膀胱炎

Outline of Final Research Achievements

Interstitial cystitis are refractory disease with unknown etiology. There is no radical treatment so far. The aim of our study is to create disease model animal of chronic inflammation and investigate the effectiveness of intravesical infusion of adipose stem cells on the disease model animal.
First, we have tried to create a chronic cystitis rats and mice model in the beginning. Lipopolysaccharide derived from E. coli and protamine sulfate was instilled into mourine bladder to destroy the mucosal surface, and inflammation was identified histologically, in 2013. Next year, we performed the functional study by bladder cystometry. A result, although the model showed frequent urination, voided volume did not decreased and failed to show similarity with interstitial cystitis in functional study.

Free Research Field

泌尿器科学