Roles of prostaglandin receptor subtype EP4 in the induction of overactive bladder

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592428
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: ARAKI Isao 滋賀医科大学, 医学部, 客員教授 (50252424)
• Co-Investigator(Kenkyū-buntansha): TSURU Teruhiko 滋賀医科大学, 医学部, 助教 (90625675) ; KAGEYAMA Susumu 滋賀医科大学, 医学部, 講師 (50378452)
• Co-Investigator(Renkei-kenkyūsha): TAKEDA Masayuki 山梨大学, 大学院医学工学総合研究部, 教授 (80197318) ; KOBAYASHI Hideki 山梨大学, 医学部付属病院, 助教 (50402053)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: プロスタグランジン / 膀胱 / 排尿 / 知覚 / 求心路 / 平滑筋

Outline of Final Research Achievements

EP4 receptors were largely expressed in bladders with outlet obstruction (BOO) but absent in controls. Activation of the EP4 receptors in bladders with BOO suppressed detrusor contraction and afferent activity. EP4 receptors expressed in the bladder epithelium might regulate neuromodulator release from the epithelium. These results strongly suggest that EP4 receptor upregulation in the BOO bladder participates in a compensatory mechanism to counteract the storage dysfunction caused by BOO.

Free Research Field

排尿学