Pelvic blood flow and lower urinary tract dysfunction

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592431
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Kochi University (2013-2014); Tottori University (2012)
• Principal Investigator: SAITO Motoaki 高知大学, 教育研究部医療学系, 教授 (60273893)
• Co-Investigator(Kenkyū-buntansha): KINOSHITA Yukako 鳥取大学, 医学部, 助教 (50032214)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 骨盤内血流 / 膀胱 / 前立腺 / 前立腺過形成 / 排尿筋過活動 / SHR

Outline of Final Research Achievements

A decreased prostatic blood flow could be one of the risk factors for overactive bladder/ detrusor hyperactivity and benign prostatic hyperplasia/benign prostatic enlargement. The spontaneously hypertensive rat (SHR) shows a chronic pelvic ischemia and detrusor hyperactivity and hyperplastic morphological abnormalities in the ventral prostate. Chronic treatment with nicorandil, silodosin, hydroxyfasudil and olmesartan improved the pelvic blood flow, bladder dysfunction and prostatic hyperplasia in the SHR. These drugs can ameliorate the progression of bladder dysfunction as well as prostatic hyperplasia through an increase in the pelvic blood flow.

Free Research Field

下部尿路の薬理学