A new treatment agent determining renal calcium crystallization through cyclophilin D activation.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592434
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: FUJITA Keiji 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (50264734)
• Co-Investigator(Kenkyū-buntansha): TOZAWA Keiichi 名古屋市立大学, 大学院医学研究科, 准教授 (40264733) ; YASUI Takahiro 名古屋市立大学, 大学院医学研究科, 教授 (40326153) ; OKADA Atsushi 名古屋市立大学, 大学院医学研究科, 講師 (70444966) ; HAMAMOTO Shuzo 名古屋市立大学, 大学院医学研究科, 研究員 (80551267)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 尿路結石 / 細胞障害 / ミトコンドリア

Outline of Final Research Achievements

To experimentally evaluate the clinical application of N-methyl-4-isoleucine cyclosporin, a novel selective inhibitor of cyclophilin D activation.In vitro, calcium oxalate monohydrate crystals induced depolarization of the mitochondrial membrane potential, which was remarkably prevented by N-methyl-4-isoleucine cyclosporin. In vivo, ethylene glycol administration induced renal calcium crystallization, oxidative stress, mitochondrial collapse and cell apoptosis in rats, which were significantly prevented by N-methyl-4-isoleucine cyclosporin.

Free Research Field

医歯薬学