2014 Fiscal Year Final Research Report
Functional analysis of urinary exosome in ADPKD
| Project/Area Number |
24592439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Juntendo University (2013-2014)
Teikyo University (2012) |
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Principal Investigator |
HORIE Shigeo 順天堂大学, 医学(系)研究科(研究院), 教授 (40190243)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ADPKD / 多発性嚢胞腎 / exosome / microRNA |
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| Outline of Final Research Achievements |
Urinary exosome was isolated from either CKD Gstage4 or ADPKD patients upon consent, and the identified microRNA was compared between these 2 groups. MicroRNAs specific for Wnt/b-catenin/GSK-3, regulating Oncogenes, associated with renal cell carcinoma, tumor suppressor gene, and inhibitory for inflammation were more expressed in ADPKD.
Specific microRNAs identified from urinary exosome of ADPKD patients can be either prognostic or predictive for the clinical course of ADPKD.
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| Free Research Field |
泌尿器科学
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