2014 Fiscal Year Final Research Report
Parasympathetic nerve activity and hypoxic-ischemic brain damage in the developing fetus
| Project/Area Number |
24592476
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 低酸素虚血性脳障害 / 副交感神経 / アセチルコリン受容体 / マイクログリア / 炎症性サイトカイン / 胎児心拍数細変動 |
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| Outline of Final Research Achievements |
The fetus is parasympathetic nerve dominant in a relatively lower pO2 condition, which presumably serves as hypoxia-tolerance. To test this hypothesis, we used hypoxic-ischemic brain damage models of 7-day-old Wistar rats. As a result, acetylcholine receptor agonists improved brain damage, while its antagonists worsened them. In addition, microglia activation and inflammatory cytokine production are playing roles.
Next, we used same animal models and recorded heart rate variability during repetitive hypoxic stresses, which is represented as parasympathetic nerve activity. Repetitive hypoxia resulted in decreased baseline and responsive variability in some animals, which is more often associated with later brain damage.
These findings suggest that parasympathetic activation serves as hypoxia-tolerance and that its suppression can be detected by decreases in fetal heart rate variability during hypoxic insults.
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| Free Research Field |
周産期医学、胎児生理学、低酸素性脳障害、胎児心拍数モニタリング、産婦人科学
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