IgG transport mechanism of Fc gamma RIIb-containing compartments across the placental barrier

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592489
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Ochanomizu University
• Principal Investigator: ISHIKAWA Tomoko お茶の水女子大学, プロジェクト教育研究院, 特任准教授 (70212850)
• Co-Investigator(Kenkyū-buntansha): FUJIWARA Yoko お茶の水女子大学, 基幹研究院, 教授 (50293105)
• Co-Investigator(Renkei-kenkyūsha): TAKIZAWA Toshihiro 日本医科大学, 大学院医学研究科, 教授 (90271220) ; KIKUCHI Kunio 日本医科大学, 医学部, 講師 (70374676)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 細胞・組織 / 小胞輸送 / 免疫 / 栄養

Outline of Final Research Achievements

We performed in vitro bio-imaging analysis of IgG trafficking by FcγRIIb-containing compartments and elucidated that FcγRIIb participates in maternal IgG trafficking of placental endothelial cells and RAB3D plays a role in regulating intracellular dynamics of the FcγRIIb-containing compartments. Furthermore, we attempted to develop animal model and confirmed FcγRIIb expression level in hepatic sinusoidal endothelial cells during the diet-induced hepatic disorders.

Free Research Field

機能形態学・栄養化学