The regulation mechanism of uterine contraction: Association between Uterine myometrium and Immunological cells/oxidative stress

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592493
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kawasaki Medical School
• Principal Investigator: SHIMOYA KOICHIRO 川崎医科大学, 医学部, 教授 (40291950)
• Co-Investigator(Kenkyū-buntansha): NAKAI Yuichiro 川崎医科大学, 医学部, 准教授 (50271193) ; FUKE Shinji 川崎医科大学, 医学部, 講師 (50333696) ; CHANG Yang-Sil 川崎医科大学, 医学部, 講師 (70565910) ; TOMIMATSU Takuji 川崎医科大学, 医学部, 准教授 (30346209) ; MURATA Takuya 川崎医科大学, 医学部, 講師 (20714207)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 酸化ストレス / 母体ストレス / 子宮筋 / 子宮収縮 / サイトカイン / 嗅覚

Outline of Final Research Achievements

Aromatherapy affected maternal stress level by HPA axis. Maternal stress levels also associated with maternal sexual function, maternal general health, EPDS and mother-to-infant bonding. Maternal oxidative stress levels were associated with uterine contraction and intrauterine infection. However, fetal oxidative stress levels were lower than those of mothers. Maternal anti-oxidative levels were low, but fetal levels were higher than adult levels. IL-8, IL-17, TNF-α, and IL-23 in maternal or cord blood were associated with uterine contraction.

Free Research Field

産婦人科学・周産期医学