2014 Fiscal Year Final Research Report
Biological role of ZFP36 in gynecologic malignancies
| Project/Area Number |
24592497
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WATARI Hidemichi 北海道大学, 北海道大学病院, 講師 (10344508)
SAKURAGI Noriaki 北海道大学, 大学院医学研究科, 教授 (70153963)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | cervical cancer / CIN / HPV / ZFP36 / IMP3 |
|---|
| Outline of Final Research Achievements |
We aimed to examine the expression of RNA-binding proteins (IMP3 and ZFP36) in HPV-16-positive cervical intraepithelial neoplasia (CIN), and squamous cell carcinoma (SCC), and investigate whether their expression is correlated with disease progression of CIN2/3. Immunohistochemistry showed that higher expression of IMP3, lower expression of ZFP36 was more frequently observed in CIN3 and SCC than CIN1/2. Among CIN2/3, cases with higher IMP3 expression progressed to higher-grade lesions, whereas cases with lower IMP3 expression did not progress.We conclude that increased expression of IMP3 and/or reduced expression of ZFP36 may play a role in HPV-16-related cervical carcinogenesis. Immunohistochemical expression of IMP3 might be a useful marker to predict progression of HPV16-positive CIN2/3 to higher-grade lesions.
|
| Free Research Field |
婦人科腫瘍学
|
