The role of epigenetic effector polycomb group gene in ovarian cancers

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592502
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Yamagata University
• Principal Investigator: SUDO Takeshi 山形大学, 医学部, 医員 (70466605)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Toshifumi 山形大学, 医学部, 講師 (20302292) ; KURACHI Hirohisa 山形大学, 医学部, 非常勤講師 (40153366) ; OHTA Tsuyoshi 山形大学, 医学部, 助教 (50375341)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 卵巣癌 / 癌幹細胞 / ポリコーム複合体 / 薬剤感受性 / ハニカム膜

Outline of Final Research Achievements

We identified cancer stem-like cells (CSLC) in human ovarian cancer cell line A2780 by stem cell culture methods. The expression of polycomb group (PcG), which are epigenetic effector, showed no difference between parental A2780 and CSLC. Although cancer stem cells show the resistance to chemotherapeutic agent, A2780 CSLC did not have the ability of cisplatin resistance. Honeycomb films (3D porous scaffold) fabricated from various biodegradable polymers can amplify the cancer stem cells. Honeycomb-patterned polyurethane films inhibited cell proliferation compared with control tissue culture dish in ovarian cancer cells, suggesting that honeycomb films have the possibility of inducing cancer cell to cancer stem cell.

Free Research Field

婦人科腫瘍