Genetic mutational profiling of endometrail cancer aiming at individualized treatment

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592503
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of Tsukuba
• Principal Investigator: MINAGUCHI Takeo 筑波大学, 医学医療系, 講師 (40372396)
• Co-Investigator(Kenkyū-buntansha): YOSHIKAWA Hiroyuki 筑波大学, 医学医療系・産科婦人科学, 教授 (40158415) ; OKI Akinori 筑波大学, 医学医療系・産科婦人科学, 教授 (60334067)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: PTEN / p53 / 子宮体癌 / 遺伝子変異 / 蛋白発現 / 予後因子 / 放射線治療

Outline of Final Research Achievements

Protein exressions and genetic mutations of PTEN and p53 were analyzed and correlated with clinicopathological factors and prognosis in endometrial cancers. Negative PTEN expression was associated with endometrioid histology and absent lymphovascular invasion and was a favorable prognostic factor, while positive p53 was associated with non-endometrioid histology and advanced stage and was a poor prognostic factor. Postoperative radiotherapy improved survival only in p53 negative patients, and was a favorable prognostic factor for p53 negative patients. Accordingly, it is suggested that PTEN genetic aberration causes indolent biological property and p53 aberration causes rapid progression and low radiosensitivity, affecting endometrial cancer prognosis independently.

Free Research Field

婦人科腫瘍