2014 Fiscal Year Final Research Report
Development of new treatment strategy against endometrial cancer targeting cancer assosiated fibroblast
| Project/Area Number |
24592507
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KYO Satoru 島根大学, 医学部, 教授 (50272969)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 子宮内膜癌 / 癌線維芽細胞 / IGFBP6 |
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| Outline of Final Research Achievements |
We investigeted the strategy to target cancer associated fibroblast(CAF) for endomertial cancer treatment.Analysis of clinical sample revieled decreased expression of secreatary protein,IGFBP6,in CAF. In vitro assay using cell lines also revieled IGF-2 dependent growth of endometrial cancer is canceled by addition of IGFBP6. This result suggest the possibility of inducing IGFBP6 in CAF as a new strategy to treat endometrial cancer.
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| Free Research Field |
婦人科腫瘍
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