2014 Fiscal Year Final Research Report
Devoleping a novel anti-angiogenic therapy focused on placental growth factor secreted by ovarian cancer cells
| Project/Area Number |
24592515
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAWADA Kenjiro 大阪大学, 医学系研究科, 講師 (00452392)
MABUCHI Seiji 大阪大学, 医学系研究科, 助教 (00452441)
ISOBE Aki 大阪大学, 医学系研究科, 助教 (60397619)
HASHIMOTO Kae 大阪大学, 医学系研究科, 助教 (90612078)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 卵巣癌 / 抗血管新生療法 / NF-κB シグナル / VEGF |
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| Outline of Final Research Achievements |
The improvement of outcome in patients with ovarian cancer by an anti-angiogenic therapy has been shown in large clinical trials. However, the only option currently available is the anti-VEGF-A antibody, which efficacy is limited. Therefore, we aim to develop a new anti-angiogenic drug for ovarian cancer. As NF-κB signaling has the potential to regulate several angiogenic factors including VEGF-A, we determined to identify the significance of NF-κB activation in ovarian cancer and to investigate the possibility of a novel NF-κB inhibitor as an anti-angiogenic drug. Immunohistochemical analyses using ovarian cancer tissues showed that NF-κB activation is an independent prognostic factor. A specific NF-κB inhibitor led to the inhibition of angiogenesis in vitro and in vivo. In a xenograft model, the treatment of NF-κB inhibitor significantly suppressed peritoneal dissemination. Anti-angiogenic therapy targeting NF-κB signaling is a potential future option to treat ovarian cancer.
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| Free Research Field |
医歯薬学
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