Investigation of a candidate protein associated with chemo-resistance of endometrial carcinomas

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592516
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka University
• Principal Investigator: UEDA Yutaka 大阪大学, 医学(系)研究科(研究院), 助教 (10346215)
• Co-Investigator(Kenkyū-buntansha): ENOMOTO Takayuki 大阪大学, 医学系研究科, 招へい教員 (90283754) ; FUJITA Masami 大阪大学, 医学系研究科, 招へい准教授 (60303963) ; YOSHINO Kiyoshi 大阪大学, 医学系研究科, 准教授 (90362730) ; KIMURA Toshihiro 大阪大学, 医学系研究科, 招へい教員 (90584524) ; KOBAYASHI Eiji 大阪大学, 医学系研究科, 助教 (50614773)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 婦人科腫瘍 / 子宮体癌 / 化学療法 / 抵抗性 / 蛋白質発現

Outline of Final Research Achievements

Enhanced expression of Annexin A4 (Anx A4) increases chemoresistance to plutinum through increased extracellular efflux of the drug. Exposure to platinum drugs induced relocation of Anx A4 from the cytoplasm to the cellular membrane, where it became colocalized with ATP7A, a copper transporter also well known as a mechanism of platinum efflux. Calcium-binding site in the annexin repeat induces chemoresistance to the platinum drug by elevating the intracellular chloride.

Free Research Field

医歯薬学