Elucidation of regulatory mechanism of estrogen in epithelial ovarian cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592521
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kumamoto University
• Principal Investigator: MOTOHARA Ken-ichi 熊本大学, 医学部附属病院, 非常勤診療医師 (50573606)
• Co-Investigator(Kenkyū-buntansha): KATABUCHI Hidetaka 熊本大学, 生命科学研究部, 教授 (90224451) ; TASHIRO Hironori 熊本大学, 生命科学研究部, 教授 (70304996) ; MIYAHARA Yo 熊本大学, 生命科学研究部, 非常勤診療医師 (40404355)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 卵巣表層上皮 / 卵巣癌 / 癌幹細胞

Outline of Final Research Achievements

Human ovarian surface epithelium (OSE) is thought to be the origin of most of human ovarian carcinomas. Recent evidence suggests that normal ovarian epithelial stem cells exist in OSE in some mouse models. Here we show that the established immortalized OSE cell lines and the transformed tumorigenic OSE cell lines contain epithelial stem-like cells. Furthermore, RT-PCR analysis demonstrated that these stem-like cell population express various stem cell-related genes. We next plan to check the 17β-HSD expression in these stem-like cell population.

Free Research Field

産婦人科学