2015 Fiscal Year Final Research Report
Establishment of an antibody that targets carbohydrate structures specific to metastatic gynaecological malignancies
| Project/Area Number |
24592530
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOMINGA Eiichiro 慶應義塾大学, 医学部, 講師 (80276328)
SUZUKI Masami 慶應義塾大学, 医学部, 研究員 (10276321)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 糖鎖抗原 / 抗体 |
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| Outline of Final Research Achievements |
We established the humanized HMMC-1 antibody which recognizes gynecologic cancers and demonstrates specific anti-tumor activity towards endometrial cancer. In vitro, the antibody demonstrated anti-tumor activity towards endometrial cancer cells with differing lymph node metastasis potential and demonstrated even greater cell proliferation inhibitory effects towards the cell line with greater metastatic potential. Cell cycle analysis demonstrated that this difference in proliferation inhibition was not due to differences in proliferation or cell cycle. In addition, we elucidated the carbohydrate antigen recognized by the HMMC-1 antibody. Using mass spectrometry, we showed that the HMMC-1 antibody recognizes CD 166 and CD 49. Our research thus delineates the future possibility of clinical treatments based on HMMC-1 antibody administration as molecular target therapy towards endometrial cancer cases that demonstrate elevated CD 166 expression levels.
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| Free Research Field |
婦人科腫瘍学
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