Expressioon of Adenomatous Polyposis Coli protein in the mouse cochlea.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592538
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Tohoku University
• Principal Investigator: KATORI Yukio 東北大学, 医学(系)研究科(研究院), 教授 (20261620)
• Co-Investigator(Kenkyū-buntansha): KAWASE Tetsuaki 東北大学, 大学院医工学研究科, 教授 (50169728) ; KUDO Takayuki 東北大学, 大学院医学系研究科, 非常勤講師 (80451590)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 蝸牛 / 聴覚 / アクチン / APC蛋白 / 免疫組織化学

Outline of Final Research Achievements

Actin is one of the important cytoskeletal protein which manage the structural integrity and polarity of sensory hair cell and supporting cell in the cochlea. Adenomatous polyposis coli (APC) protein is known to modulate arrangement of actin molecule, thus the APC protein may act an important role for the cochlear function. The localization of the APC protein in adult mice cochleae have been investigated using an immunofluorescence histochemistry.　The APC protein is expressed in the interdental cell near the cochlear modiolus and in the type two fibrocyte located near the outer ridge of basilar membrane. In these area, APC protein could organize the structural integrity of the cochlear epithelium and basilar membrane. On the other hands, the APC protein was not investigated in both sensory hair cells and nearby supporting cells. In those cells of adult mice, the other molecules could modulate the arrangement and the polarity of the actin molecule.

Free Research Field

耳鼻咽喉科学