2016 Fiscal Year Final Research Report
Effects of ceramide and sphingolipids on cochlear injury
| Project/Area Number |
24592541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Tabuchi Keiji 筑波大学, 医学医療系, 講師 (80361335)
|
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| Project Period (FY) |
2012-04-01 – 2017-03-31
|
| Keywords | 内耳 / 蝸牛 / シスプラチン |
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| Outline of Final Research Achievements |
Ceramide and sphingosine increased cochlear injury induced by cisplatin. Ceramide and sphingosine themselves induced cochlear injury without cisplatin at high doses.On the other hand, ceramide-1-phosphate (C1P) decreased cochlear injury induced by cisplatin. Inhibition of ceramide kinase which converted ceramide to C1P significantly worsened cochlear injury induced by ceramide. Intrinsic cochlear ceramide kinase protected the cochlea against ototoxicity.
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| Free Research Field |
耳鼻咽喉科
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