Elucidation and treatment strategies for protraction of chronic otitis media by genetic analysis of methicillin-resistant Staphylococcus aureus

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592552
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kochi University
• Principal Investigator: KOMORI Masahiro 高知大学, 教育研究部医療学系, 講師 (30565742)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Taisuke 高知大学, 教育研究部医療学系, 准教授 (30253313)
• Co-Investigator(Renkei-kenkyūsha): UEHARA Yoshio 高知大学, 教育研究部医療学系, 助教 (60346723)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 黄色ブドウ球菌 / MRSA / 慢性中耳炎

Outline of Final Research Achievements

Staphylococcus aureus causes about 50% of cases of chronic otitis media (COM). It is postulated that population structure of S. aureus is geographically different in regions or diseases such as impetigo and atopic dermatitis. This study demonstrated that population structure of S. aureus in COM did not reflect that of nasal strains in healthy volunteers, but rather it was specific to the disease.
The relationships among the virulence of methicillin-resistant Staphylococcus aureus (MRSA) strains, their antibiotic susceptibility, and the presence of enterotoxin genes have been frequently discussed.The minimum inhibitory concentrations(MIC) of vancomycin was high for both hospital-associated(HA) and community-associated(CA) MRSA strains, and the MIC of linezolid was higher in CA-MRSA strains. More toxigenic genes were identified in HA-MRSA strains than in CA-MRSA strains.

Free Research Field

耳鼻咽喉科学